[{"code":"C28944","name":"Cream Dosage Form","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"definitions":[{"definition":"A semi-solid composed of an emulsion of lipids, hydrocarbons, waxes, or polyols in water.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"A semisolid emulsion of either the oil-in-water or the water-in-oil type, ordinarily intended for topical use. (NCI)","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Semi-solid single-dose or multidose preparation of homogeneous appearance consisting of a lipophilic phase and an aqueous phase, one of which is finely dispersed in the other. Active substance(s) are dissolved or dispersed in the basis, which may be hydrophilic or hydrophobic. Creams are intended for cutaneous use. In certain cases, transdermal delivery may be obtained.","code":"P325","type":"ALT_DEFINITION","source":"EDQM-HC"}]},{"code":"C29167","name":"Lotion Dosage Form","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"definitions":[{"definition":"A semi-solid composed of an oil in water emulsion, with lower viscosity than cream or gel.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"An emulsion, liquid (1) dosage form. This dosage form is generally for external application to the skin (2). Note 1: A liquid is pourable; it flows and conforms to its container at room temperature. It displays Newtonian or pseudoplastic flow behavior. Note 2: Previously the definition of a lotion was: The term lotion has been used to categorize many topical suspensions, solutions, and emulsions intended for application to the skin. The current definition of a lotion is restricted to an emulsion.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"}]},{"code":"C42934","name":"Gel Dosage Form","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"definitions":[{"definition":"A semi-solid composed of a solid, three dimensional, cross linked matrix of polymers within a liquid, yielding a jelly-like material unable to flow at steady state.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"A semisolid (1) dosage form that contains a gelling agent to provide stiffness to a solution or a colloidal dispersion (2). A gel may contain suspended particles. Note 1: A semisolid is not pourable; it does not flow or conform to its container at room temperature. It does not flow at low shear stress and generally exhibits plastic flow behavior. Note 2: A colloidal dispersion is a system in which particles of colloidal dimension (i.e., typically between 1 nm and 1 micrometer) are distributed uniformly throughout a liquid.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Semi-solid single-dose or multidose preparation consisting of a single-phase basis of liquids gelled by a suitable gelling agent, intended for cutaneous use. Active substance(s) are dissolved or dispersed in the basis, which may be hydrophilic or hydrophobic.","code":"P325","type":"ALT_DEFINITION","source":"EDQM-HC"}]},{"code":"C42966","name":"Ointment Dosage Form","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"definitions":[{"definition":"A semi-solid, viscous in texture, that may be composed of a variety of bases including hydrocarbons, emulsifiers or vegetable oils, and mixed with active and/or inert ingredient(s).","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"A substance used on the skin to soothe or heal wounds, burns, rashes, scrapes, or other skin problems.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"A suspension or emulsion, semisolid (1) dosage form, usually containing less than 20 percent water and volatiles (2) and greater than 50 percent hydrocarbons, waxes, or polyols as the vehicle. This dosage form is generally for external application to the skin or mucous membranes. Note 1: A semisolid is not pourable; it does not flow or conform to its container at room temperature. It does not flow at low shear stress and generally exhibits plastic flow behavior. Note 2: Percent water and volatiles are measured by a loss on drying test in which the sample is heated at 105 degrees C until constant weight is achieved.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Semi-solid single-dose or multidose preparation consisting of a single-phase basis in which solids or liquids may be dispersed. Active substance(s) are dissolved or dispersed in the basis, which may be hydrophilic, hydrophobic or water-emulsifying. Ointments are intended for cutaneous use. In certain cases, transdermal delivery may be obtained.","code":"P325","type":"ALT_DEFINITION","source":"EDQM-HC"}]},{"code":"C42986","name":"Solution Dosage Form","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"definitions":[{"definition":"A clear, homogeneous liquid composed of one or more chemical substances dissolved in a solvent or mixture of mutually miscible solvents.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"A clear, homogeneous liquid dosage form that contains one or more chemical substances dissolved in a solvent or mixture of mutually miscible solvents. Note: A liquid is pourable; it flows and conforms to its container at room temperature. It displays Newtonian or pseudoplastic flow behavior.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"A constituent that is a clear, homogeneous liquid containing one or more chemical substances dissolved in a solvent or mixture of mutually miscible solvents.","code":"P325","type":"ALT_DEFINITION","source":"PQCMC"}]}]