{"total":2,"timeTaken":44,"parameters":{"term":"UBX-303061","type":"contains","include":"definitions,synonyms","fromRecord":0,"pageSize":10,"terminology":["ncit"]},"concepts":[{"code":"C213051","name":"BTK Degrader UBX-303061","terminology":"ncit","version":"26.10d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"BTK Degrader UBX-303061","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"BTK Degrader UBX-303061","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"UBX 303061","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"UBX-303061","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"UBX303061","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BTK Degrader UBX-303061","type":"Display_Name","typeCode":"P107"},{"name":"BTK Degrader UBX-303061","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"An orally bioavailable chimeric degrader of Bruton's tyrosine kinase (BTK) comprised of an E3 ubiquitin ligase ligand conjugated to a BTK-binding ligand, with potential antineoplastic activity. Upon oral administration, BTK degrader UBX-303061 specifically targets and binds, with its BTK-targeting moiety, to BTK and the E3 ubiquitin ligase ligand moiety binds to E3 ubiquitin ligase. This catalyzes ubiquitination and proteasome-mediated degradation of BTK, and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.","code":"P97","type":"DEFINITION","source":"NCI"}]},{"code":"C70993","name":"Tether Containing UBX Domain For GLUT4","terminology":"ncit","version":"26.10d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Tether Containing UBX Domain For GLUT4","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Alveolar Soft Part Sarcoma Chromosomal Region Candidate Gene 1 Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alveolar Soft Part Sarcoma Chromosome Region Candidate 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alveolar Soft Part Sarcoma Locus","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ASPSCR1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Renal Papillary Cell Carcinoma Protein 17","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tether Containing UBX Domain For GLUT4","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"UBX Domain-Containing Protein 9","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tether Containing UBX Domain For GLUT4","type":"Display_Name","typeCode":"P107"},{"name":"Tether Containing UBX Domain For GLUT4","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Tether containing UBX domain for GLUT4 protein (553 aa, ~60 kDa) is encoded by the human ASPSCR1 gene. This protein is involved in the regulation of glucose transport and sequestration.","code":"P97","type":"DEFINITION","source":"NCI"}]}]}