{"code":"C943","name":"Vitamin K","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CRCH"},{"name":"Vitamin K","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CRCH"},{"name":"Vitamin K","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"vitamin K","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000046044"},{"name":"Vitamin K","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Vitamin K","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NICHD"},{"name":"Vitamin K","type":"Display_Name","typeCode":"P107"},{"name":"Vitamin K","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A nutrient that the body needs in small amounts to function and stay healthy. Vitamin K helps to form blood clots (a mass that forms when blood platelets, proteins, and cells stick together) and maintain strong bones. It is fat-soluble (can dissolve in fats and oils) and is found in green leafy vegetables, broccoli, liver, and vegetable oils. Vitamin K is also made by bacteria that live in the large intestine. Not enough vitamin K can lead to bleeding and bruising.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"Fat soluble vitamin that is a coenzyme during the synthesis of the biologically active form of a number of proteins involved in blood coagulation and bone metabolism. Vitamin K's structure typically consists of a methylated naphthoquinone ring from which one or more unsaturated aliphatic side chains are attached at the 3-position of the ring.","code":"P325","type":"ALT_DEFINITION","source":"CRCH"},{"definition":"The term \"vitamin K\" refers to a group of chemically similar fat-soluble compounds called naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones) are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble preparation available for adults only. Vitamin K is necessary for the liver to produce the coagulation factors II, VII, IX, and X, as well as the clotting factors protein C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these coagulation factors and excess bleeding. An injection of vitamin K is routinely given to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic disease of the newborn. Vitamin K deficiency is rare in adults but may result from chronic malnutrition or an inability to absorb dietary vitamins.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P210","type":"CAS_Registry","value":"12001-79-5"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:28384"},{"code":"P350","type":"Chemical_Formula","value":"C31H46O2"},{"code":"P322","type":"Contributing_Source","value":"CRCH"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"NICHD"},{"code":"P353","type":"INFOODS","value":"VITK"},{"code":"P366","type":"Legacy Concept Name","value":"Vitamin_K"},{"code":"P359","type":"Micronutrient","value":"Y"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"786611"},{"code":"P358","type":"Nutrient","value":"Y"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"786611"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"786611"},{"code":"P106","type":"Semantic_Type","value":"Vitamin"},{"code":"P207","type":"UMLS_CUI","value":"C0042878"},{"code":"P355","type":"Unit","value":"mcg"},{"code":"P351","type":"US_Recommended_Intake","value":"Y"},{"code":"P354","type":"USDA_ID","value":"430"}]}