{"code":"C91335","name":"Coagulation Factor V","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Coagulation Factor V","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Activated Protein C Cofactor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Coagulation Factor V","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"F5","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Factor V","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Labile Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Proaccelerin, Labile Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Coagulation Factor V","type":"Display_Name","typeCode":"P107"},{"name":"Coagulation Factor V","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Coagulation factor V (2224 aa, ~252 kDa) is encoded by the human F5 gene. This protein plays a role in the coagulation cascade.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Coagulation factor V has no activity until it is cleaved by thrombin into two chains, called coagulation factor V heavy chain and coagulation factor V light chain. The two chains are non-covalently bound in a complex, factor Va, which is a cofactor that enhances the enzymatic activity of coagulation factor Xa."},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"612309"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P12259"},{"code":"P207","type":"UMLS_CUI","value":"C0015498"}]}