{"code":"C79964","name":"Transthyretin","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Transthyretin","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"ATTR","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Prealbumin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TBPA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Thyroxine-Binding Prealbumin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Transthyretin","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TTR","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Transthyretin","type":"Display_Name","typeCode":"P107"},{"name":"Transthyretin","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Transthyretin (147 aa, ~16 kDa) is encoded by the human TTR gene. This protein is involved in both the binding and transport of retinol and thyroxine.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Transthyretin is a homotetramer with two thyroxine binding sites. Less than 1% of plasma transthyretin is involved in thyroxine transport, while 40% is in a tight protein-protein complex with the plasma retinol-binding protein (RBP). The formation of the complex with RBP stabilizes the binding of retinol to RBP and decreases the glomerular filtration and renal catabolism of the RBP molecule. (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Transthyretin"},{"code":"P208","type":"NCI_META_CUI","value":"CL1374644"},{"code":"P100","type":"OMIM_Number","value":"176300"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P02766"}]}