{"code":"C74960","name":"Alpha-Tocopherol","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CRCH"},{"name":"Alpha-tocopherol","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CRCH"},{"name":"Alpha-Tocopherol","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":".ALPHA.-TOCOPHEROL","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"H4N855PNZ1","subSource":"UNII"},{"name":"3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-Tocopherol","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-Tocopherol","type":"Display_Name","typeCode":"P107"},{"name":"Alpha-Tocopherol","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities.  Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"Tocopherol with three methyl groups on its chromanol ring.","code":"P325","type":"ALT_DEFINITION","source":"CRCH"}],"properties":[{"code":"P210","type":"CAS_Registry","value":"1406-18-4"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:18145"},{"code":"P350","type":"Chemical_Formula","value":"C29H50O2"},{"code":"P322","type":"Contributing_Source","value":"CRCH"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P319","type":"FDA_UNII_Code","value":"H4N855PNZ1"},{"code":"P353","type":"INFOODS","value":"TOCPHA"},{"code":"P366","type":"Legacy Concept Name","value":"Alpha-Tocopherol"},{"code":"P360","type":"Macronutrient","value":"Y"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"775583"},{"code":"P208","type":"NCI_META_CUI","value":"CL938214"},{"code":"P358","type":"Nutrient","value":"Y"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"775583"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"775583"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P106","type":"Semantic_Type","value":"Vitamin"},{"code":"P355","type":"Unit","value":"mg"},{"code":"P354","type":"USDA_ID","value":"323"}]}