{"code":"C739","name":"Phenobarbital","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Phenobarbital","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"DCP","code":"00018"},{"name":"PHENOBARBITAL","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"YQE403BP4D","subSource":"UNII"},{"name":"phenobarbital","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000045470"},{"name":"5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PHENO","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Phenobarbital","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Phenobarbital","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain.  The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P302","type":"Accepted_Therapeutic_Use_For","value":"Epilepsy"},{"code":"P210","type":"CAS_Registry","value":"50-06-6"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:8069"},{"code":"P350","type":"Chemical_Formula","value":"C12H12N2O3"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P319","type":"FDA_UNII_Code","value":"YQE403BP4D"},{"code":"P366","type":"Legacy Concept Name","value":"Phenobarbital"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"42405"},{"code":"P175","type":"NSC Number","value":"128143"},{"code":"P175","type":"NSC Number","value":"9848"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"42405"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"42405"},{"code":"P106","type":"Semantic_Type","value":"Organic Chemical"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P207","type":"UMLS_CUI","value":"C0031412"}]}