{"code":"C69076","name":"Rindopepimut","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Rindopepimut","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"RINDOPEPIMUT","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"K3L4X0501F","subSource":"UNII"},{"name":"Anti-EGFRvIII Vaccine CDX-110","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CDX-110","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"L-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Megathura crenulata)","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PF-04948568","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Rindopepimut","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Rindopepimut","type":"Display_Name","typeCode":"P107"},{"name":"Rindopepimut","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with rindopepimut may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P302","type":"Accepted_Therapeutic_Use_For","value":"Immunotherapy for glioblastoma multiforme"},{"code":"P210","type":"CAS_Registry","value":"1108208-65-6"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P322","type":"Contributing_Source","value":"GDC"},{"code":"P319","type":"FDA_UNII_Code","value":"K3L4X0501F"},{"code":"P366","type":"Legacy Concept Name","value":"Anti-EGFRvIII_Vaccine_CDX-110"},{"code":"P375","type":"Maps_To","value":"Rindopepimut"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"546970"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"546970"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"546970"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P207","type":"UMLS_CUI","value":"C3181262"}],"parents":[{"code":"C1663","name":"Antineoplastic Vaccine"}],"associations":[{"code":"A8","type":"Concept_In_Subset","relatedCode":"C116978","relatedName":"CTRP Agent Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C116977","relatedName":"CTRP Terminology"},{"code":"A7","type":"Has_Target","relatedCode":"C101140","relatedName":"EGFR NP_005219.2:p.V30_R297delinsG"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C63923","relatedName":"FDA Established Names and Unique Ingredient Identifier Codes Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C157711","relatedName":"GDC Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C157712","relatedName":"GDC Therapeutic Agent Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C177537","relatedName":"GDC Value Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C176424","relatedName":"NCI Drug Dictionary Terminology"},{"code":"A8","type":"Concept_In_Subset","relatedCode":"C128784","relatedName":"NCIt Antineoplastic Agent Terminology"},{"code":"A32","type":"Is_Value_For_GDC_Property","relatedCode":"C1909","relatedName":"Pharmacologic Substance"}],"inverseAssociations":[{"code":"A31","type":"Has_GDC_Value","relatedCode":"C1909","relatedName":"Pharmacologic Substance"}],"history":[{"code":"C69076","action":"create","date":"2007-08-31"},{"code":"C69076","action":"modify","date":"2007-12-03"},{"code":"C69076","action":"modify","date":"2008-02-01"},{"code":"C69076","action":"modify","date":"2009-11-23"},{"code":"C69076","action":"modify","date":"2010-08-16"},{"code":"C69076","action":"modify","date":"2010-08-23"},{"code":"C69076","action":"modify","date":"2010-08-30"},{"code":"C69076","action":"modify","date":"2010-09-07"},{"code":"C69076","action":"modify","date":"2010-09-13"},{"code":"C69076","action":"modify","date":"2010-09-20"},{"code":"C69076","action":"modify","date":"2010-09-27"},{"code":"C69076","action":"modify","date":"2010-11-08"},{"code":"C69076","action":"modify","date":"2012-12-10"},{"code":"C69076","action":"modify","date":"2014-08-04"},{"code":"C69076","action":"modify","date":"2014-08-18"},{"code":"C69076","action":"modify","date":"2014-09-22"},{"code":"C69076","action":"modify","date":"2016-08-29"},{"code":"C69076","action":"modify","date":"2018-01-29"},{"code":"C69076","action":"modify","date":"2018-04-30"},{"code":"C69076","action":"modify","date":"2018-07-30"},{"code":"C69076","action":"modify","date":"2019-02-25"},{"code":"C69076","action":"modify","date":"2020-12-28"},{"code":"C69076","action":"modify","date":"2021-03-29"},{"code":"C69076","action":"modify","date":"2021-04-26"},{"code":"C69076","action":"modify","date":"2021-05-24"},{"code":"C69076","action":"modify","date":"2023-07-31"},{"code":"C69076","action":"modify","date":"2025-02-24"},{"code":"C69076","action":"modify","date":"2026-02-23"},{"code":"C69076","action":"modify","date":"2026-09-28"}],"maps":[{"type":"Has Synonym","targetName":"Rindopepimut","targetTermType":"PT","targetCode":"therapeutic_agents","targetTerminology":"GDC"}]}