{"code":"C62216","name":"Gamma-Enolase","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"NSE","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"caDSR"},{"name":"Gamma-Enolase","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"NSE","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"GDC"},{"name":"2-Phospho-D-Glycerate Hydro-Lyase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"EC 4.2.1.11","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ENO2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Enolase 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Gamma-Enolase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neural Enolase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neuron-Specific Enolase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Phosphopyruvate Hydratase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Gamma-Enolase","type":"Display_Name","typeCode":"P107"},{"name":"Gamma-Enolase","type":"Preferred_Name","typeCode":"P108"},{"name":"NSE","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"PCDC","subSource":"EWS"}],"definitions":[{"definition":"Gamma-enolase (434 aa, ~47 kDa) is encoded by the human ENO2 gene. This protein is involved in glycolysis, neurotrophy and neuroprotection.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"GDC"},{"code":"P322","type":"Contributing_Source","value":"PCDC"},{"code":"P98","type":"DesignNote","value":"Gamma-enolase is expressed specifically in neurons."},{"code":"P98","type":"DesignNote","value":"Gamma-enolase protein levels are significantly elevated in brain tumors and Creutzfeld-Jacob disease. Cardiovascular accidents and cerebral trauma also cause dramatic increases in levels of this protein."},{"code":"P366","type":"Legacy Concept Name","value":"Gamma-Enolase"},{"type":"Logical_Definition","value":"true"},{"code":"P375","type":"Maps_To","value":"NSE"},{"code":"P100","type":"OMIM_Number","value":"131360"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P93","type":"Swiss_Prot","value":"P09104"},{"code":"P207","type":"UMLS_CUI","value":"C1880904"}]}