{"code":"C53406","name":"Citrulline","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Citrulline","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"CITRULLINE","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"29VT07BGDA","subSource":"UNII"},{"name":"2-Amino-5-(carbamoylamino)pentanoic Acid","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Citrulline","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"L-Citrulline","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"N5-(Aminocarbonyl)-L-ornithine","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Citrulline","type":"Display_Name","typeCode":"P107"},{"name":"Citrulline","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P210","type":"CAS_Registry","value":"372-75-8"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:16349"},{"code":"P350","type":"Chemical_Formula","value":"C6H13N3O3"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P319","type":"FDA_UNII_Code","value":"29VT07BGDA"},{"code":"P366","type":"Legacy Concept Name","value":"Citrulline"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"464795"},{"code":"P175","type":"NSC Number","value":"27425"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"464795"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"464795"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P207","type":"UMLS_CUI","value":"C0008864"}]}