{"code":"C49184","name":"Loop Diuretic","terminology":"ncit","version":"26.08e","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"Loop Diuretic","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Loop Diuretic","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Any agent belonging to the class of loop diuretics. Loop diuretics block and inhibit the function of the sodium-potassium-chloride (Na+, K+, Cl-) cotransporter system in the thick ascending limb of the loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, magnesium, ammonium and water.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P366","type":"Legacy Concept Name","value":"Loop_Diuretic"},{"code":"P106","type":"Semantic_Type","value":"Chemical Viewed Functionally"},{"code":"P207","type":"UMLS_CUI","value":"C3536704"}],"children":[{"code":"C219118","name":"Azosemide Meglumine","leaf":true},{"code":"C77515","name":"Azosemide","leaf":true},{"code":"C28875","name":"Bumetanide","leaf":true},{"code":"C223737","name":"Ethacrynate Calcium Dihydrate","leaf":true},{"code":"C47993","name":"Ethacrynate Sodium","leaf":true},{"code":"C485","name":"Ethacrynic Acid","leaf":true},{"code":"C65600","name":"Etozolin","leaf":true},{"code":"C219189","name":"Furosemide Diethylaminoethanol","leaf":true},{"code":"C217930","name":"Furosemide Sodium","leaf":true},{"code":"C219190","name":"Furosemide Xantinol","leaf":true},{"code":"C515","name":"Furosemide","leaf":true},{"code":"C74252","name":"Galosemide","leaf":true},{"code":"C80956","name":"Indacrinone","leaf":true},{"code":"C80957","name":"Lemidosul","leaf":true},{"code":"C175151","name":"Muzolimine","leaf":true},{"code":"C66289","name":"Ozolinone","leaf":true},{"code":"C218193","name":"Piretanide Sodium","leaf":true},{"code":"C66419","name":"Piretanide","leaf":true},{"code":"C74250","name":"Sulosemide","leaf":true},{"code":"C152613","name":"Ticrynafen","leaf":true},{"code":"C218963","name":"Torasemide Sodium","leaf":true},{"code":"C29506","name":"Torsemide","leaf":true}],"parents":[{"code":"C448","name":"Diuretic"}],"history":[{"code":"C49184","action":"create","date":"2005-12-01"},{"code":"C49184","action":"modify","date":"2008-03-28"},{"code":"C49184","action":"modify","date":"2009-11-23"},{"code":"C49184","action":"modify","date":"2010-08-02"},{"code":"C49184","action":"modify","date":"2011-12-19"},{"code":"C49184","action":"modify","date":"2021-04-26"},{"code":"C49184","action":"modify","date":"2021-10-25"},{"code":"C49184","action":"modify","date":"2026-02-23"}]}