{"code":"C38897","name":"CD3 Complex","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"CD3","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"caDSR"},{"name":"CD3 Complex","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"caDSR"},{"name":"CD3 Complex","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"CD3","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"GDC"},{"name":"CD3","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CD3 Complex","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T-Cell Surface Glycoprotein CD3","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T3 Complex","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CD3 Complex","type":"Display_Name","typeCode":"P107"},{"name":"CD3 Complex","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D), one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex is a T-cell co-receptor that noncovalently associates with either the disulfide bound heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation of and cellular propagation of the signal by CD247 and the CD3 complex.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"GDC"},{"code":"P366","type":"Legacy Concept Name","value":"CD3_Complex"},{"code":"P375","type":"Maps_To","value":"CD3"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P207","type":"UMLS_CUI","value":"C0108779"}]}