{"code":"C38041","name":"Troponin T","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"Troponin T","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"TNNT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TnT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Troponin T","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Troponin T","type":"Display_Name","typeCode":"P107"},{"name":"Troponin T","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. Troponin T binds tropomyosin to the troponin complex and inhibits F-actin-myosin interactions. The troponin T gene family comprises three isoforms: slow skeletal (TNNT1), cardiac (TNNT2) and fast skeletal (TNNT3). Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"Troponin_T"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P207","type":"UMLS_CUI","value":"C0077404"}]}