{"code":"C37962","name":"Haptoglobin","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Haptoglobin","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Haptoglobin","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"HP","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Zonulin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Haptoglobin","type":"Display_Name","typeCode":"P107"},{"name":"Haptoglobin","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Haptoglobin (406 aa, ~45 kDa) is encoded by the human HP gene. This protein plays a role in tight junction disassembly, intestinal permeability, heme iron recycling, antimicrobial activity and the regulation of hydrogen peroxide catabolism.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Although homologous to serine proteases, haptoglobin is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt)"},{"code":"P98","type":"DesignNote","value":"Binding free plasma hemoglobin, secreted haptoglobin prevents loss of iron through the kidneys, protects the kidneys from oxidative damage by hemoglobin (Hb), and makes hemoglobin accessible to degradative enzymes. Hp/Hb clearance appears to be mediated by the monocyte/macrophage scavenger receptor CD163. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, by allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Haptoglobin"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"140100"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P00738"},{"code":"P207","type":"UMLS_CUI","value":"C1505203"}]}