{"code":"C34026","name":"Growth/Differentiation Factor 15","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Growth/Differentiation Factor 15","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"GDF-15","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"GDF15","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Growth/Differentiation Factor 15","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Macrophage Inhibitory Cytokine 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Macrophage Inhibitory Cytokine-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Macrophage-Inhibiting Cytokine 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"MIC1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NAG-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NAG1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NRG-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NRG1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NSAID (Nonsteroidal Anti-Inflammatory Drug)-Activated Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NSAID-Activated Gene 1 Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NSAID-Activated Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NSAID-Regulated Gene 1 Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NSAID-Regulated Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PDF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Placental Bone Morphogenic Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Placental TGF-Beta","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Prostate Differentiation Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Prostate-Derived Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PTGF-Beta","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PTGFB","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Growth/Differentiation Factor 15","type":"Display_Name","typeCode":"P107"},{"name":"Growth/Differentiation Factor 15","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Growth/differentiation factor 15 (308 aa, ~34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"The active form of growth/differentiation factor 15 is produced by a proteolytic processing that removes 194 N-terminal amino acids from the full length precursor protein. (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Placental_TGF-Beta"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"605312"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"Q99988"},{"code":"P207","type":"UMLS_CUI","value":"C1431343"}]}