{"code":"C28482","name":"Coagulation Factor IX","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Christmas Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"COAGULATION FACTOR IX","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Factor IX","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"FIX","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Coagulation Factor IX","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Christmas Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Coagulation Factor IX","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"EC 3.4.21.22","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"F9","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Factor 9","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Factor IX","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasma Thromboplastic Component","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasma Thromboplastin Component","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PTC","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Coagulation Factor IX","type":"Display_Name","typeCode":"P107"},{"name":"Coagulation Factor IX","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"An antigen encoded by the F9 gene and plays a role in the intrinsic pathway of blood coagulation through the mediation of proteolysis that converts factor X into an active protease.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Coagulation factor IX (461 aa, ~52 kDa) is encoded by the human F9 gene. This protein plays a role in the intrinsic pathway of blood coagulation through the mediation of proteolysis that converts factor X into an active protease.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CDISC"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Coagulation factor IX is converted from a zymogen to an active protease through a single proteolytic cleavage by either coagulation factor XIa or a complex containing tissue factor and coagulation factor IIVa."},{"code":"P366","type":"Legacy Concept Name","value":"Coagulation_Factor-IX"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"300746"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P93","type":"Swiss_Prot","value":"P00740"},{"code":"P207","type":"UMLS_CUI","value":"C0015491"}]}