{"code":"C25293","name":"Alanine Aminotransferase","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"Alanine Aminotransferase","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"alanine transferase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372944"},{"name":"serum glutamate pyruvate transaminase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372943"},{"name":"SGPT","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372947"},{"name":"Alanine Aminotransferase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alanine Transaminase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ALAT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ALT","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"EC 2.6.1.2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serum Glutamate-Pyruvate Transaminase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serum Glutamic-Pyruvic Transaminase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SGPT (ALT)","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alanine Aminotransferase","type":"Display_Name","typeCode":"P107"},{"name":"Alanine Aminotransferase","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A family of pyridoxal phosphate-dependent enzymes involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Alanine aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-alanine to alpha-ketoglutarate forming pyruvate and L-glutamate.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"An enzyme found in the liver and other tissues. A high level of serum glutamate pyruvate transaminase released into the blood may be a sign of liver damage, cancer, or other diseases.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"SGPT-ALT_Protein"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P207","type":"UMLS_CUI","value":"C0376147"}]}