{"code":"C25202","name":"Aspartate Aminotransferase","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"Aspartate Aminotransferase","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"aspartate transaminase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372942"},{"name":"serum glutamic-oxaloacetic transaminase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372941"},{"name":"SGOT","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000372945"},{"name":" AspAT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"AAT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ASAT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Aspartate Aminotransferase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Aspartate Transaminase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"AST","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"EC 2.6.1.1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Glutamic Oxaloacetic Transaminase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"GOT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SGOT (AST)","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Aspartate Aminotransferase","type":"Display_Name","typeCode":"P107"},{"name":"Aspartate Aminotransferase","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A family of pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. Aspartate aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-aspartate to alpha-ketoglutarate forming oxaloacetate and L-glutamate.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"An enzyme found in the liver, heart, and other tissues. A high level of serum glutamic-oxaloacetic transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Urea Cycle, Tricarboxylic Acid Cycle, Transamination"},{"code":"P366","type":"Legacy Concept Name","value":"SGOT-AST_Protein"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P207","type":"UMLS_CUI","value":"C0242192"}]}