{"code":"C25184","name":"Lactate Dehydrogenase","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"Lactate Dehydrogenase","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"lactate dehydrogenase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000354462"},{"name":"lactic acid dehydrogenase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000354463"},{"name":"LDH","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000354465"},{"name":"EC 1.1.1.27","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"L-(+)-Lactate Dehydrogenase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"L-Lactic Acid Dehydrogenase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lactate Dehydrogenase","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lactic Acid Dehydrogenase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"LDH","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NAD-Lactate Dehydrogenase","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lactate Dehydrogenase","type":"Display_Name","typeCode":"P107"},{"name":"Lactate Dehydrogenase","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. An increased amount of lactate dehydrogenase in the blood may be a sign of tissue damage and some types of cancer or other diseases.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"Lactate_Dehydrogenase"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P207","type":"UMLS_CUI","value":"C0022917"}]}