{"code":"C20535","name":"Tumor Necrosis Factor","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Tumor Necrosis Factor","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"TNF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNF Alpha","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNF-a","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNF-A","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNF-Alpha","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNFA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TNFSF2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tumor Necrosis Factor","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tumor Necrosis Factor Alpha","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tumor Necrosis Factor Ligand Superfamily Member 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tumor Necrosis Factor-Alpha","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tumor Necrosis Factor","type":"Display_Name","typeCode":"P107"},{"name":"Tumor Necrosis Factor","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Tumor necrosis factor (233 aa, ~26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the stimulation of cell proliferation and the positive regulation of cell differentiation.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Tumor necrosis factor (TNF) is a serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants."},{"code":"P366","type":"Legacy Concept Name","value":"Tumor_Necrosis_Factor-Alpha"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"191160"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P93","type":"Swiss_Prot","value":"P01375"},{"code":"P207","type":"UMLS_CUI","value":"C1448177"}]}