{"code":"C20514","name":"Interleukin-12","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Interleukin-12","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"CLMF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Cytotoxic Lymphocyte Maturation Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-12","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-12 p70","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-12p70","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL12","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin 12","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-12","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Natural Killer Cell Stimulatory Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NKSF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-12","type":"Display_Name","typeCode":"P107"},{"name":"Interleukin-12","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"Interleukin-12"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P207","type":"UMLS_CUI","value":"C0123759"}]}