{"code":"C20512","name":"Interleukin-10","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Interleukin-10","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"IL-10","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000682069"},{"name":"interleukin-10","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000557293"},{"name":"CSIF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Cytokine Synthesis Inhibitory Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-10","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL10","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin 10","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-10","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T-Cell Growth Inhibitory Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TGIF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-10","type":"Display_Name","typeCode":"P107"},{"name":"Interleukin-10","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway."},{"code":"P366","type":"Legacy Concept Name","value":"Interleukin-10"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"124092"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P93","type":"Swiss_Prot","value":"P22301"},{"code":"P207","type":"UMLS_CUI","value":"C1699802"}]}