{"code":"C20508","name":"Interleukin-4","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Interleukin-4","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"IL-4","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000044420"},{"name":"interleukin-4","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000045209"},{"name":"B Cell Proliferating Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Differentiation Factor-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Growth Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Growth Factor-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Stimulating Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Stimulation Factor-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Stimulatory Factor 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BCDF-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BCGF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BCGF-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BCSF 1","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BSF-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BSF1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-4","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL4","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL4 Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin 4","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-4","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-4 Precursor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lymphocyte Stimulatory Factor 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Mast Cell Growth Factor-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"MCGF 2","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T-Cell Growth Factor 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-4","type":"Display_Name","typeCode":"P107"},{"name":"Interleukin-4","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-4 is made by a type of T lymphocyte. It causes B lymphocytes to increase and to make antibodies and also increases the production of T lymphocytes. Interleukin-4 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-4 is a type of cytokine.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"Interleukin-4"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"147780"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P93","type":"Swiss_Prot","value":"P05112"},{"code":"P207","type":"UMLS_CUI","value":"C1701589"}]}