{"code":"C20473","name":"Interleukin-8","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Interleukin-8","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Alveolar Macrophage Chemotactic Factor I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Anionic Neutrophil Activating Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Anionic Neutrophil-Activating Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta Endothelial Cell-Derived Neutrophil Activating Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta-Thromboglobulin-Like Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"C-X-C Motif Chemokine 8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CXCL8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"GCP-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"GCP-IL-8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Granulocyte Chemotactic Peptide Interleukin 8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Granulocyte Chemotactic Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin 8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-8","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Leukocyte Adhesion Inhibitor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lung Giant Cell Carcinoma-Derived Chemotactic Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Lymphocyte Derived Neutrophil Activating Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Macrophage-Derived Chemotactic Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"MDNCF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"MONAP","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Monocyte-Derived Neutrophil Chemotactic Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Monocyte-Derived Neutrophil-Activating Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"NAP-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neutrophil Activation Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neutrophil Activation Peptide","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neutrophil Chemotactic Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neutrophil-Activating Peptide 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Neutrophil-Activating Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Protein 3-10C","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T-Cell Chemotactic Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-8","type":"Display_Name","typeCode":"P107"},{"name":"Interleukin-8","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Interleukin-8 is cleaved into the following seven chains: MDNCF-a (GCP/IL-8 protein IV, IL8/NAP1 form I), Interleukin-8 ((Ala-IL-8)77, GCP/IL-8 protein II, IL-8(1-77), IL8/NAP1 form II, MDNCF-b), IL-8(5-77), IL-8(6-77) ((Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, neutrophil-activating factor, NAF), IL-8(7-77) (GCP/IL-8 protein V, IL8/NAP1 form IV), IL-8(8-77) (GCP/IL-8 protein VI, IL8/NAP1 form V), and IL-8(9-77) (GCP/IL-8 protein III; IL8/NAP1 form VI). (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Interleukin-8"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"146930"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P93","type":"Swiss_Prot","value":"P10145"},{"code":"P207","type":"UMLS_CUI","value":"C1698756"}]}