{"code":"C20451","name":"Interleukin-6","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Interleukin-6","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"IL-6","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000044421"},{"name":"interleukin-6","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000044045"},{"name":"B Cell Differentiation Factor 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Differentiation Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Stimulatory Factor 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B-Cell Stimulatory Factor-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BSF-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"BSF2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CDF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CTL Differentiation Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Hepatocyte Stimulating Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Hepatocyte Stimulatory Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"HGF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"HPGF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"HSF","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Hybridoma Growth Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IFN Beta 2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IFN-Beta-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IFNB2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL-6","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL6","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IL6 Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interferon Beta-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interferon, Beta-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin 6","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin BSF-2","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-6","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Myeloid Differentiation Inducing Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasmacytoma Growth Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Sigosix","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Interleukin-6","type":"Display_Name","typeCode":"P107"},{"name":"Interleukin-6","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells.","code":"P97","type":"DEFINITION","source":"NCI"},{"definition":"One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine. Also called IL-6.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P366","type":"Legacy Concept Name","value":"Interleukin-6"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"147620"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Immunologic Factor"},{"code":"P93","type":"Swiss_Prot","value":"P05231"},{"code":"P207","type":"UMLS_CUI","value":"C1698754"}]}