{"code":"C178619","name":"Complement Component C8","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"C8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Complement C8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Complement Component 8","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Complement Component C8","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Complement Component C8","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A heterotrimeric protein complex composed of complement component 8 (C8) chains alpha, beta and gamma. The alpha and gamma chains form a disulfide-linked dimer that is noncovalently associated with the beta chain. C8 inserts itself into target cell membranes following formation of the C5b-6-7 complex and then recruits 10-16 molecules of C9 to complete the formation of the membrane attack complex.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P208","type":"NCI_META_CUI","value":"CL1648593"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"}]}