{"code":"C17284","name":"Chromogranin-A","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Chromogranin-A","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"CgA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"CHGA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Chromogranin A","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Chromogranin-A","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Parathyroid Secretory Protein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Pituitary Secretory Protein I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PSP","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Secretory Protein I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SP-I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Chromogranin-A","type":"Display_Name","typeCode":"P107"},{"name":"Chromogranin-A","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Chromogranin-A (457 aa, ~51 kDa) is encoded by the human CHGA gene. This protein plays a role in the modulation of both blood pressure and pancreatic release of insulin.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Chromogranin-A is a precursor that is cleaved to produce more than 20 biologically active peptides including: vasostatin-1, vasostatin-2, EA-92, ES-43, pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, catestatin (SL21), GV-19, GR-44, ER-37, GE-25, parastatin, chromofungin, chromostatin (CST), serpinin-RRG, serpinin and p-Glu serpenin precursor."},{"code":"P366","type":"Legacy Concept Name","value":"Chromogranin-A"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"118910"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Hormone"},{"code":"P93","type":"Swiss_Prot","value":"P10645"},{"code":"P207","type":"UMLS_CUI","value":"C0055633"}]}