{"code":"C16995","name":"Tissue-Type Plasminogen Activator","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Tissue-Type Plasminogen Activator","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"tissue plasminogen activator","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000377718"},{"name":"tPA","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000377721"},{"name":"EC 3.4.21.68","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PLAT","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"t-PA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"T-Plasminogen Activator","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tissue Plasminogen Activator","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tissue-Type Plasminogen Activator","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"TPA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tissue-Type Plasminogen Activator","type":"Display_Name","typeCode":"P107"},{"name":"Tissue-Type Plasminogen Activator","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator is a type of systemic thrombolytic agent.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"Tissue-type plasminogen activator (562 aa, ~63 kDa) is encoded by the human PLAT gene. This protein plays a role in the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin, tissue kallikrein or factor Xa to a two chain disulfide linked protein. The two chain form demonstrates increased levels of plasminogen-plasmin converting activity when compared to the single chain form."},{"code":"P366","type":"Legacy Concept Name","value":"Tissue_Plasminogen_Activator"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"173370"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P93","type":"Swiss_Prot","value":"P00750"},{"code":"P207","type":"UMLS_CUI","value":"C0084796"}]}