{"code":"C16947","name":"Plasminogen Activator Inhibitor 1","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Plasminogen Activator Inhibitor 1","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Endothelial Plasminogen Activator Inhibitor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Nexin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PAI","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PAI-1","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PAI1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"PLANH1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasminogen Activator Inhibitor 1","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasminogen Activator Inhibitor Type 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasminogen Activator Inhibitor-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serine or Cysteine Proteinase Inhibitor Clade E Member 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serpin E1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SERPINE1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Plasminogen Activator Inhibitor 1","type":"Display_Name","typeCode":"P107"},{"name":"Plasminogen Activator Inhibitor 1","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Plasminogen activator inhibitor 1 (402 aa, ~45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the modulation of plasmin activity.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Plasminogen Activator Inhibitor-1 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators.  PAI1 shows structural similarities to angiotensinogen, alpha-1-antitrypsin, and antithrombin III and also regulates motility through the interaction of vitronectin with its receptor, integrin alpha-V-beta-3.  (from OMIM 173360)"},{"code":"P366","type":"Legacy Concept Name","value":"Plasminogen_Activator_Inhibitor-1"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"173360"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P05121"},{"code":"P207","type":"UMLS_CUI","value":"C0030190"}]}