{"code":"C16743","name":"Insulin-Like Growth Factor I","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Insulin-Like Growth Factor I","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"IGF I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IGF-1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IGF-I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"IGF1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Insulin-Like Growth Factor 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Insulin-Like Growth Factor I","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Insulin-Like Growth Factor-I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Mechano Growth Factor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"MGF","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Somatomedin C","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Somatomedin-C","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Insulin-Like Growth Factor I","type":"Display_Name","typeCode":"P107"},{"name":"Insulin-Like Growth Factor I","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Insulin-like growth factor I (195 aa, ~22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (Int J Cancer. 2000; 88: 828-832, via Medscape)"},{"code":"P98","type":"DesignNote","value":"Similar to insulin, the full length insulin-like growth factor I precursor protein is cleaved at positions 48 and 188 to release a 70 amino acid growth factor and a 77 amino acid E peptide. (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Insulin-Like_Growth_Factor-1"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"147440"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P05019"},{"code":"P207","type":"UMLS_CUI","value":"C3712803"}]}