{"code":"C16687","name":"Histone","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"HISTONE","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Histone","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"histone family","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"GDC","code":"VAR"},{"name":"histone_family","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"GDC","code":"VAR"},{"name":"histone","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000318814"},{"name":"Histone","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Histone","type":"Display_Name","typeCode":"P107"},{"name":"Histone","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A type of protein found in chromosomes. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"Any antigen(s) of the histone nuclear protein family. They can be considered as autoantigens and are commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Major protein component of chromatin.  Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein.  The various classes are now termed H1, H2A, H2B, H3, and H4.  In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes.  The histones in the octamer complex are also known as the core histones.  The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P368","type":"CHEBI_ID","value":"CHEBI:15358"},{"code":"P322","type":"Contributing_Source","value":"CDISC"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"GDC"},{"code":"P366","type":"Legacy Concept Name","value":"Histone"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P207","type":"UMLS_CUI","value":"C0019652"}]}