{"code":"C16570","name":"Coagulation Factor VII","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Coagulation Factor VII","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"EC 3.4.21.21","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"F7","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Factor VII","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Proconvertin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serum Prothrombin Conversion Accelerator","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Coagulation Factor VII","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Coagulation factor VII (466 aa, ~52 kDa) is encoded by the human F7 gene. This protein is involved in both binding to tissue factor and the initiation of blood coagulation.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P98","type":"DesignNote","value":"Coagulation factor VII is converted from a zymogen to an active protease through a single proteolytic cleavage by by factor Xa, factor XIIa, factor IXa, or thrombin. (UniProt)"},{"code":"P366","type":"Legacy Concept Name","value":"Coagulation_Factor-VII"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"613878"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P106","type":"Semantic_Type","value":"Enzyme"},{"code":"P93","type":"Swiss_Prot","value":"P08709"},{"code":"P207","type":"UMLS_CUI","value":"C0015502"}]}