{"code":"C16278","name":"Alpha-Fetoprotein","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Alpha-Fetoprotein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"caDSR"},{"name":"Alpha-Fetoprotein","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"alpha-Fetoprotein","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"DCP","code":"05864"},{"name":"AFP","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000044861"},{"name":"alpha-fetoprotein","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000046208"},{"name":"AFP","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha Fetal Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha Fetoprotein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-1-Fetoprotein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-Fetoglobulin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-Fetoprotein","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Alpha-Fetoprotein","type":"Display_Name","typeCode":"P107"},{"name":"Alpha-Fetoprotein","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)"},{"code":"P366","type":"Legacy Concept Name","value":"Alpha-Fetoprotein"},{"type":"Logical_Definition","value":"true"},{"code":"P100","type":"OMIM_Number","value":"104150"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P02771"},{"code":"P207","type":"UMLS_CUI","value":"C1307640"}]}