{"code":"C142155","name":"Beta-2-Glycoprotein 1","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Apo-H","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Apolipoprotein H","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"B2GPI","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"BETA-2 GLYCOPROTEIN 1","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Beta-2-Glycoprotein I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Beta-2-Glycoprotein 1","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Activated Protein C-Binding Protein","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Anticardiolipin Cofactor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"APC Inhibitor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Apo-H","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"APOH","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Apolipoprotein H","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"B2GPI","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta(2)GPI","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta-2 Glycoprotein 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta-2-Glycoprotein 1","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta-2-Glycoprotein I","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Beta-2-Glycoprotein 1","type":"Display_Name","typeCode":"P107"},{"name":"Beta-2-Glycoprotein 1","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"An antigen of the cardiolipin-binding protein encoded by the APOH gene. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases antiphospholipid syndrome and systemic rheumatic diseases like systemic lupus erythematosus.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"Beta-2-glycoprotein 1 (345 aa, ~38 kDa) is encoded by the human APOH gene. This protein is involved in binding to phospholipids, glycosaminoglycans and other negatively charged substances.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CDISC"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Beta-2-glycoprotein 1 may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome. (EntrezGene)"},{"type":"Logical_Definition","value":"true"},{"code":"P208","type":"NCI_META_CUI","value":"CL524123"},{"code":"P100","type":"OMIM_Number","value":"138700"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P02749"}]}