{"code":"C1311","name":"Tacrolimus","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Tacrolimus","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"DCP","code":"01195"},{"name":"Tacrolimus","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"DTP","code":"NSC0717865"},{"name":"TACROLIMUS","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"WM0HAQ4WNM","subSource":"UNII"},{"name":"Tacrolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"HemOnc","code":"474"},{"name":"tacrolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000045414"},{"name":"FK 506","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"FK-506","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"FK506","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Fujimycin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Hecoria","termType":"BR","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Prograf","termType":"BR","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Protopic","termType":"BR","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tacforius","termType":"FB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tacrolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Tacrolimus","type":"Display_Name","typeCode":"P107"},{"name":"Tacrolimus","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P302","type":"Accepted_Therapeutic_Use_For","value":"Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis"},{"code":"P210","type":"CAS_Registry","value":"109581-93-3"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:61057"},{"code":"P350","type":"Chemical_Formula","value":"C44H69NO12.H2O"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P322","type":"Contributing_Source","value":"HemOnc"},{"code":"P319","type":"FDA_UNII_Code","value":"WM0HAQ4WNM"},{"code":"P366","type":"Legacy Concept Name","value":"Tacrolimus"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"42009"},{"code":"P175","type":"NSC Number","value":"717865"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"42009"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"42009"},{"code":"P106","type":"Semantic_Type","value":"Organic Chemical"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P207","type":"UMLS_CUI","value":"C0085149"}]}