{"code":"C1212","name":"Sirolimus","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Sirolimus","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Sirolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"DCP","code":"20504"},{"name":"RAPAMYCIN","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"DTP","code":"NSC0226080"},{"name":"SIROLIMUS","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"FDA","code":"W36ZG6FT64","subSource":"UNII"},{"name":"Sirolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"HemOnc","code":"468"},{"name":"Rapamune","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000580375"},{"name":"rapamycin","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000285947"},{"name":"sirolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI-GLOSS","code":"CDR0000045513"},{"name":"9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2","termType":"SN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"AY 22989","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"AY-22989","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"AY22989","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"RAPA","termType":"AB","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Rapamune","termType":"BR","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Rapamycin","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SILA 9268A","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SILA-9268A","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SILA9268A","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Sirolimus","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"WY 090217","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"WY-090217","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"WY090217","termType":"CN","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Sirolimus","type":"Display_Name","typeCode":"P107"},{"name":"Sirolimus","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.","code":"P325","type":"ALT_DEFINITION","source":"NCI-GLOSS"},{"definition":"A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P302","type":"Accepted_Therapeutic_Use_For","value":"Kidney transplant rejection, prevention"},{"code":"P210","type":"CAS_Registry","value":"53123-88-9"},{"code":"P368","type":"CHEBI_ID","value":"CHEBI:9168"},{"code":"P350","type":"Chemical_Formula","value":"C51H79NO13"},{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P322","type":"Contributing_Source","value":"FDA"},{"code":"P322","type":"Contributing_Source","value":"GDC"},{"code":"P322","type":"Contributing_Source","value":"HemOnc"},{"code":"P319","type":"FDA_UNII_Code","value":"W36ZG6FT64"},{"code":"P366","type":"Legacy Concept Name","value":"Sirolimus"},{"code":"P375","type":"Maps_To","value":"Sirolimus"},{"code":"P399","type":"NCI_Drug_Dictionary_ID","value":"42555"},{"code":"P175","type":"NSC Number","value":"226080"},{"code":"P330","type":"PDQ_Closed_Trial_Search_ID","value":"42555"},{"code":"P329","type":"PDQ_Open_Trial_Search_ID","value":"42555"},{"code":"P106","type":"Semantic_Type","value":"Antibiotic"},{"code":"P106","type":"Semantic_Type","value":"Organic Chemical"},{"code":"P106","type":"Semantic_Type","value":"Pharmacologic Substance"},{"code":"P207","type":"UMLS_CUI","value":"C0072980"}]}