{"code":"C116161","name":"Multiplex Ligation-dependent Probe Amplification","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"MLPA","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"CDISC"},{"name":"Multiplex Ligation-dependent Probe Amplification","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Multiplex Ligation-dependent Probe Amplification","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"A type of high-throughput, multiplex PCR method that uses a single pair of PCR primers to amplify multiple targets and to determine changes in complex genomes.","code":"P325","type":"ALT_DEFINITION","source":"CDISC"},{"definition":"A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a single pair of PCR primers. It is frequently used in the detection of genetic aberrations in tumors, and can distinguish sequences differing in only a single nucleotide.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CDISC"},{"code":"P106","type":"Semantic_Type","value":"Molecular Biology Research Technique"},{"code":"P207","type":"UMLS_CUI","value":"C3494189"}]}