{"code":"C114757","name":"P-glycoprotein Inhibitor","terminology":"ncit","version":"26.08e","conceptStatus":"DEFAULT","leaf":false,"active":true,"synonyms":[{"name":"P-gp inhibitor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"caDSR"},{"name":"P-glycoprotein Inhibitor","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"P-gp Inhibitor","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"P-glycoprotein Inhibitor","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Any agent that inhibits the efflux pump p-glycoprotein (P-gp).","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P106","type":"Semantic_Type","value":"Chemical Viewed Functionally"},{"code":"P207","type":"UMLS_CUI","value":"C3500483"}],"children":[{"code":"C2231","name":"Dofequidar Fumarate","leaf":true},{"code":"C65458","name":"Dofequidar","leaf":true},{"code":"C223709","name":"Encequidar Hydrochloride","leaf":true},{"code":"C188262","name":"Encequidar Mesylate","leaf":true},{"code":"C111994","name":"Encequidar","leaf":true},{"code":"C28698","name":"Laniquidar","leaf":true},{"code":"C218341","name":"Tariquidar Dimesylate","leaf":true},{"code":"C2246","name":"Tariquidar","leaf":true},{"code":"C2225","name":"Zosuquidar Trihydrochloride","leaf":true},{"code":"C76198","name":"Zosuquidar","leaf":true}],"parents":[{"code":"C1744","name":"Multidrug Resistance Modulator"}],"history":[{"code":"C114757","action":"create","date":"2014-04-14"},{"code":"C114757","action":"modify","date":"2018-10-29"},{"code":"C114757","action":"modify","date":"2018-10-29"},{"code":"C114757","action":"modify","date":"2019-09-30"},{"code":"C114757","action":"modify","date":"2020-09-29"},{"code":"C114757","action":"modify","date":"2021-10-25"},{"code":"C114757","action":"modify","date":"2025-12-29"},{"code":"C114757","action":"modify","date":"2026-02-23"}]}