{"code":"C104683","name":"Antithrombin-III","terminology":"ncit","version":"26.09d","conceptStatus":"DEFAULT","leaf":true,"active":true,"synonyms":[{"name":"Antithrombin-III","termType":"DN","type":"FULL_SYN","typeCode":"P90","source":"CTRP"},{"name":"Antithrombin III","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Antithrombin-III","termType":"PT","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"ATIII","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serine-Cysteine Proteinase Inhibitor Clade C Member 1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Serpin C1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"SERPINC1","termType":"SY","type":"FULL_SYN","typeCode":"P90","source":"NCI"},{"name":"Antithrombin-III","type":"Display_Name","typeCode":"P107"},{"name":"Antithrombin-III","type":"Preferred_Name","typeCode":"P108"}],"definitions":[{"definition":"Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.","code":"P97","type":"DEFINITION","source":"NCI"}],"properties":[{"code":"P322","type":"Contributing_Source","value":"CTRP"},{"code":"P98","type":"DesignNote","value":"Antithrombin-III can inhibit thrombin, matriptase-3/TMPRSS7, and coagulation factors IXa, Xa and Xia. (UniProt)"},{"type":"Logical_Definition","value":"true"},{"code":"P208","type":"NCI_META_CUI","value":"CL360008"},{"code":"P100","type":"OMIM_Number","value":"107300"},{"code":"P106","type":"Semantic_Type","value":"Amino Acid, Peptide, or Protein"},{"code":"P93","type":"Swiss_Prot","value":"P01008"}]}